Millsboro is a somewhat small coastal town (i.e. on the ocean, a bay, or inlet) located in the state of Delaware. With a population of 7,426 people and 11 associated neighborhoods, Millsboro is the 12th largest community in Delaware. Millsboro has seen a significant amount of newer housing growth in recent years. Quite often, new home construction is the result of new residents moving in who are middle class or wealthier, attracted by jobs, a healthy local economy, or other amenities as they leave nearby or far away areas for greener pastures. This seems to be the case in Millsboro, where the median household income is $64,622.00.

A relatively large number of people in Millsboro telecommute to their jobs. Overall, about 8.07% of the workforce works from home. While this may seem like a small number, as a fraction of the total workforce it ranks among the highest in the country. These workers are often telecommuters who work in knowledge-based, white-collar professions. For example, Silicon Valley has large numbers of people who telecommute. Other at-home workers may be self-employed people who operate small businesses out of their homes.

Millsboro is also nautical, which means that parts of it are somewhat historic and touch the ocean or tidal bodies of water, such as inlets and bays. Quite often, nautical areas such as these attract visitors and locals who come to enjoy the scenery and various waterfront activities.

The education level of Millsboro citizens is very high relative to the national average among all cities (21.84%): 35.07% of adults in Millsboro have a bachelor's degree or even advanced degree.

The per capita income in Millsboro in 2022 was $34,247, which is middle income relative to Delaware and the nation. This equates to an annual income of $136,988 for a family of four. However, Millsboro contains both very wealthy and poor people as well.

Millsboro is an extremely ethnically-diverse town. The people who call Millsboro home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of Millsboro residents report their race to be White, followed by Black or African-American. Important ancestries of people in Millsboro include Irish, English, German, Italian, and Scottish.

The most common language spoken in Millsboro is English. Other important languages spoken here include Spanish and Italian.